CLK3 and ZNF263

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CLK3	ZNF263
Description		CDC like kinase 3	zinc finger protein 263
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton	Nucleus
	Molecular Function	RNA Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways			Generic Transcription Pathway
Drugs		5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Craniofacial microsomia ( 26853712)
Interacting Genes		19 interacting genes: APP CLK2 HOXB6 HOXB7 KRTAP10-3 NEDD4 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RSRP1 SDCBP SLAMF7 SRPK2 SUV39H1 TINF2 YWHAG ZNF263	15 interacting genes: CLK2 CLK3 DVL2 EFEMP2 GPATCH2L NME7 PCBD1 PLEKHF2 SCAND1 SPG21 SUFU TCAF1 TRIM41 ZNF446 ZSCAN1
Entrez ID		1198	10127
HPRD ID		04290	05008
Ensembl ID		ENSG00000179335	ENSG00000006194
Uniprot IDs		B3KRI8 P49761	D3DUC1 O14978
PDB IDs		2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT
Enriched GO Terms of Interacting Partners?
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