CLK3 and PRMT5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
38

Data Source:
BioGRID (two hybrid)

		CLK3	PRMT5
Description		CDC like kinase 3	protein arginine methyltransferase 5
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex
	Molecular Function	RNA Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways			snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs		5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Craniofacial microsomia ( 26853712)	Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		19 interacting genes: APP CLK2 HOXB6 HOXB7 KRTAP10-3 NEDD4 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RSRP1 SDCBP SLAMF7 SRPK2 SUV39H1 TINF2 YWHAG ZNF263	79 interacting genes: ARGLU1 CALU CAPN1 CCAR2 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EZH2 FAM76B GLI1 GRHL3 GTPBP2 H2AC20 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		1198	10419
HPRD ID		04290	04955
Ensembl ID		ENSG00000179335	ENSG00000100462
Uniprot IDs		B3KRI8 P49761	B4DV00 O14744
PDB IDs		2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S
Enriched GO Terms of Interacting Partners?
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