Description |
vascular endothelial growth factor A |
AKT serine/threonine kinase 1 |
Image |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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Diseases |
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GWAS |
- Adiponectin levels ( 22479202)
- Advanced age-related macular degeneration ( 26691988)
- Age-related macular degeneration ( 23455636 21665990)
- Blood protein levels ( 30072576 29875488)
- Body mass index ( 25673413)
- Chronic kidney disease ( 20383146)
- Coronary artery disease ( 29212778)
- Coronary heart disease ( 22319020)
- Creatinine levels ( 31015462 29124443 29403010)
- Cytokine levels ( 31679650)
- Cytokine network levels (multivariate analysis) ( 31679650)
- Diastolic blood pressure ( 30224653)
- Estimated glomerular filtration rate ( 31015462 29124443 30604766)
- Fasting glucose change (short-term) ( 31263163)
- Glomerular filtration rate ( 27588450 29403010)
- Glomerular filtration rate (creatinine) ( 28452372 26831199)
- Glomerular filtration rate in non diabetics (creatinine) ( 26831199)
- HDL cholesterol ( 24097068)
- HDL cholesterol levels ( 28334899 30698716)
- HDL cholesterol levels in current drinkers ( 30698716)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
- Heel bone mineral density ( 30598549)
- Hematocrit ( 27863252)
- Hemoglobin concentration ( 27863252)
- High density lipoprotein cholesterol levels ( 29403010)
- High light scatter reticulocyte percentage of red cells ( 27863252)
- Hyperthyroidism ( 30367059)
- Hyperuricemia ( 29124443)
- Hypothyroidism ( 27182965)
- Interleukin-10 levels ( 27989323)
- Interleukin-12p70 levels ( 27989323)
- Interleukin-13 levels ( 27989323)
- Interleukin-7 levels ( 27989323)
- Medication use (calcium channel blockers) ( 31015401)
- Medication use (HMG CoA reductase inhibitors) ( 31015401)
- Metabolic syndrome ( 31589552)
- Myeloid white cell count ( 27863252)
- Plasma thyroid-stimulating hormone levels ( 28333968)
- Prostate-specific antigen levels ( 28139693)
- Red blood cell count ( 27863252)
- Reticulocyte count ( 27863252)
- Reticulocyte fraction of red cells ( 27863252)
- Serum uric acid levels ( 30993211 29124443)
- Sexual dimorphism in anthropometric traits ( 23754948)
- Thyroid hormone levels ( 23408906)
- Thyroid stimulating hormone levels ( 25743335)
- Triglyceride levels ( 28334899 29403010 30698716)
- Triglyceride levels in current drinkers ( 30698716)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)
- Triglycerides ( 24097068 25961943)
- Type 2 diabetes ( 18372903 24509480 30054458 29358691 30297969)
- Urate levels ( 31578528 23263486)
- Urinary albumin-to-creatinine ratio ( 31630189)
- Vascular endothelial growth factor levels ( 26910538 27989323 31217265)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in inactive individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412 28448500)
- Waist-hip ratio ( 25673412 20935629)
- Waist-to-hip ratio adjusted for BMI ( 26426971)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500)
- White blood cell count ( 27863252)
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Interacting Genes |
32 interacting genes:
ADAMTS1
AKT1
CCN2
CRYAB
ELAVL1
EPHB2
FLT1
FN1
GPC1
HIF1A
HNRNPD
IGFBP7
KDR
LYVE1
MDM2
NRP1
NRP2
PGF
PRRG4
SEMA3F
SP1
SP3
SPARC
TFAP2A
TNXB
U2AF1
UBIAD1
VEGFB
VPS35
VTN
YBX1
YBX3
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308 interacting genes:
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BLVRA
BPGM
BRAF
BRCA1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNB1
CYLD
DAB2IP
DCTN1
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FZR1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
METTL1
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NF1
NF2
NGB
NOL4
NOS3
NOTCH1
NR4A1
NSD3
OSGIN1
PAK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCB
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
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Entrez ID |
7422 |
207 |
HPRD ID |
01889 |
01261 |
Ensembl ID |
ENSG00000112715
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ENSG00000142208
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Uniprot IDs |
A0A024RD33
A0A024RD37
A0A0Y0IMM4
A2A2V4
P15692
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B0LPE5
B3KVH4
P31749
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PDB IDs |
1BJ1
1CZ8
1FLT
1KAT
1KMX
1MJV
1MKG
1MKK
1QTY
1TZH
1TZI
1VGH
1VPF
1VPP
2FJG
2FJH
2QR0
2VGH
2VPF
3BDY
3P9W
3QTK
3S1B
3S1K
3V2A
4DEQ
4GLN
4GLS
4KZN
4QAF
4WPB
4ZFF
5DN2
5FV1
5FV2
5HHC
5HHD
5O4E
5T89
6BFT
6D3O
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1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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