MYH9 and ASCC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYH9	ASCC2
Description		myosin heavy chain 9	activating signal cointegrator 1 complex subunit 2
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GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Cell Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion COP9 Signalosome Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Extracellular Exosome Myosin II Filament	Nucleus Nucleoplasm Nuclear Speck Activating Signal Cointegrator 1 Complex
	Molecular Function	Microfilament Motor Activity RNA Binding Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Protein Domain Specific Binding Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Membrane Anchor ADP Binding Cadherin Binding Actin Filament Binding	Ubiquitin Binding
	Biological Process	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	DNA Dealkylation Involved In DNA Repair Regulation Of Transcription, DNA-templated
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis	ALKBH3 mediated reversal of alkylation damage
Drugs
Diseases		Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Optic nerve measurement (rim area) ( 20395239)	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		24 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ	40 interacting genes: ASCC3 ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		4627	84164
HPRD ID		01177	16515
Ensembl ID		ENSG00000100345	ENSG00000100325
Uniprot IDs		A0A024R1N1 P35579	A0A024R1E1 A0A024R1F9 Q9H1I8
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO	2DI0
Enriched GO Terms of Interacting Partners?
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