ASS1 and USP4

Number of citations of the paper that reports this interaction (PubMedID 23022198)
4

Data Source:
BioGRID (two hybrid)

		ASS1	USP4
Description		argininosuccinate synthase 1	ubiquitin specific peptidase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Exosome Cell Body Fiber	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane
	Molecular Function	RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Identical Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Circadian Rhythm Response To Zinc Ion Response To Mycotoxin Response To Estradiol Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface
Pathways		Urea cycle	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs		L-Arginine L-Aspartic Acid L-Aspartic Acid L-Citrulline L-Citrulline ATP
Diseases		Citrullinemia (CTLN)
GWAS			Blood protein levels ( 28240269) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 MLH1 MT2A NUP214 PMPCA PTPN1 STOM TERF1 TERF2 USP4	47 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A CIAO2B HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		445	7375
HPRD ID		04590	04598
Ensembl ID		ENSG00000130707	ENSG00000114316
Uniprot IDs		P00966 Q5T6L4	A0A024R2X6 A1LPW7 Q08AK7 Q13107
PDB IDs		2NZ2	2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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