ASGR1 and CERS2

Number of citations of the paper that reports this interaction (PubMedID 11543633)
12

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ASGR1	CERS2
Description		asialoglycoprotein receptor 1	ceramide synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways		Asparagine N-linked glycosylation	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)	Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		14 interacting genes: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 LAMTOR5 LMNA NLK RBBP6 TG VKORC1	9 interacting genes: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		432	29956
HPRD ID		00151	06080
Ensembl ID		ENSG00000141505	ENSG00000143418
Uniprot IDs		P07306 Q6FGQ5	Q96G23
PDB IDs		1DV8 5JPV 5JQ1
Enriched GO Terms of Interacting Partners?
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