ASGR1 and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23241634)
1

Data Source:
BioGRID (two hybrid)

		ASGR1	LAMTOR5
Description		asialoglycoprotein receptor 1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Lysosome Lysosomal Membrane Cytosol Ragulator Complex
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Asparagine N-linked glycosylation	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)
Interacting Genes		14 interacting genes: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 LAMTOR5 LMNA NLK RBBP6 TG VKORC1	32 interacting genes: ALB ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 DBI EEF1A1 GAPDH GIT1 GPRASP1 LAMTOR4 LRIF1 MAF1 MCPH1 MEOX2 MT2A NCOA6 PDK1 RABIF RBP4 SERPINA1 TAF9 TGFB1 TOP2B TP53 UTP14A YTHDC1 ZBTB16
Entrez ID		432	10542
HPRD ID		00151	09773
Ensembl ID		ENSG00000141505	ENSG00000134248
Uniprot IDs		P07306 Q6FGQ5	A0A0C4DGV4 O43504
PDB IDs		1DV8 5JPV 5JQ1	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG
Enriched GO Terms of Interacting Partners?
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