CERS2 and ASGR2

Number of citations of the paper that reports this interaction (PubMedID 11543633)
12

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CERS2	ASGR2
Description		ceramide synthase 2	asialoglycoprotein receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Endocytosis Cell Surface Receptor Signaling Pathway Viral Process Protein N-linked Glycosylation Via Asparagine Bone Mineralization Regulation Of Protein Stability Lipid Homeostasis
Pathways		Sphingolipid de novo biosynthesis	Asparagine N-linked glycosylation
Drugs			Antihemophilic factor, human recombinant
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Blood protein levels ( 29875488) Congenital heart disease (maternal effect) ( 28468790) Total cholesterol levels ( 30275531)
Interacting Genes		9 interacting genes: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6	8 interacting genes: ASGR1 CERS2 F8 GLP1R GLUD1 HES1 MROH5 VKORC1
Entrez ID		29956	433
HPRD ID		06080	00152
Ensembl ID		ENSG00000143418	ENSG00000161944
Uniprot IDs		Q96G23	P07307 Q7Z4G9
PDB IDs
Enriched GO Terms of Interacting Partners?
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