CERS2 and SLC22A1

Number of citations of the paper that reports this interaction (PubMedID 11543633)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CERS2	SLC22A1
Description		ceramide synthase 2	solute carrier family 22 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Acetylcholine Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Epinephrine Transport Norepinephrine Uptake Ammonium Transmembrane Transport Dopamine Uptake Acetate Ester Transport
Pathways		Sphingolipid de novo biosynthesis	Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Gout ( 22179738) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 26034056 21743057) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995)
Interacting Genes		9 interacting genes: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6	3 interacting genes: CERS2 OS9 POU2AF1
Entrez ID		29956	6580
HPRD ID		06080	04007
Ensembl ID		ENSG00000143418	ENSG00000175003
Uniprot IDs		Q96G23	O15245
PDB IDs
Enriched GO Terms of Interacting Partners?
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