CERS2 and ASGR1

Number of citations of the paper that reports this interaction (PubMedID 11543633)
12

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CERS2	ASGR1
Description		ceramide synthase 2	asialoglycoprotein receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus
Pathways		Sphingolipid de novo biosynthesis	Asparagine N-linked glycosylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)	Liver enzyme levels (alkaline phosphatase) ( 22001757) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)
Interacting Genes		9 interacting genes: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6	14 interacting genes: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 LAMTOR5 LMNA NLK RBBP6 TG VKORC1
Entrez ID		29956	432
HPRD ID		06080	00151
Ensembl ID		ENSG00000143418	ENSG00000141505
Uniprot IDs		Q96G23	P07306 Q6FGQ5
PDB IDs			1DV8 5JPV 5JQ1
Enriched GO Terms of Interacting Partners?
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