MITF and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 16029420)
27

Data Source:
BioGRID (pull down)

		MITF	PIAS2
Description		melanocyte inducing transcription factor	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of RNA Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		SUMOylation of transcription factors	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS) Malignant melanoma
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 27863252) Severe influenza A (H1N1) infection ( 26379185) Systolic blood pressure ( 27841878)
Interacting Genes		29 interacting genes: APP CTNNB1 EBP EP300 FBXO7 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		4286	9063
HPRD ID		01138	06944
Ensembl ID		ENSG00000187098	ENSG00000078043
Uniprot IDs		A0A087WXU1 B4DNC7 O75030 Q8WYR3	A0A024RC49 O75928 Q2TA77
PDB IDs		4C7N	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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