MEOX1 and NEIL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MEOX1	NEIL2
Description		mesenchyme homeobox 1	nei like DNA glycosylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nucleoplasm Cytoplasm Spindle Microtubule Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Somite Specification Multicellular Organism Development Biological_process Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development	Base-excision Repair Nucleotide-excision Repair Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs			Iron Copper
Diseases
GWAS		Fractures ( 30158200)	Alcohol dependence ( 23942779) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		33 interacting genes: ACBD4 ALOX5 APP APPL1 BANP CIAO1 CIB3 CKS1B CWF19L2 CYFIP1 DCX FMR1 LMNA MAPK9 MEF2A MID1 MORF4L1 MVP NAGK NEIL2 PAGE3 PAX1 PAX3 PRKN QRICH1 RANBP3 RBM5 SOX10 SYT17 TCEANC TXLNA UBE2R2 UBXN2B	4 interacting genes: EP300 MEOX1 REL TRIM27
Entrez ID		4222	252969
HPRD ID		02537	16406
Ensembl ID		ENSG00000005102	ENSG00000154328
Uniprot IDs		P50221	A0A024R361 Q969S2
PDB IDs			1VZP
Enriched GO Terms of Interacting Partners?
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