NEIL2

Description		nei like DNA glycosylase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Spindle Microtubule Intracellular Membrane-bounded Organelle
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Base-excision Repair Nucleotide-excision Repair Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		Iron Copper
Diseases
GWAS		Alcohol dependence ( 23942779) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		4 interacting genes: EP300 MEOX1 REL TRIM27
Entrez ID		252969
HPRD ID		16406
Ensembl ID		ENSG00000154328
Uniprot IDs		A0A024R361 Q969S2
PDB IDs		1VZP
Enriched GO Terms of Interacting Partners?
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