KPNA3 and MAT2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KPNA3	MAT2B
Description		karyopherin subunit alpha 3	methionine adenosyltransferase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Host Cell	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Viral Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Triiodothyronine/thyroxine ratio ( 30824882)	Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		33 interacting genes: APOL6 ARNT CDKN1B COIL DDX21 EPAS1 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 GTF2IRD1 HIF1A HNRNPC HSPB1 KPNB1 MAT2B MVP MYOD1 NFE2L2 NFKB1 NUP50 RBBP4 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131	12 interacting genes: APP CNIH4 FBXO25 GABRA1 KPNA3 KPNA4 MAT2A MSX2 STC1 TMED9 TRIM27 YTHDF3
Entrez ID		3839	27430
HPRD ID		03536	05701
Ensembl ID		ENSG00000102753	ENSG00000038274
Uniprot IDs		A0A024RDV7 O00505	A0A140VJP2 Q9NZL9
PDB IDs			2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?
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