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KPNA3 and CDKN1B
Number of citations of the paper that reports this interaction (PubMedID
15057270
)
49
Data Source:
HPRD
(in vitro)
KPNA3
CDKN1B
Description
karyopherin subunit alpha 3
cyclin dependent kinase inhibitor 1B
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Pore
Nucleoplasm
Cytosol
Host Cell
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Protein C-terminus Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin Binding
Hsp70 Protein Binding
Protein-containing Complex Binding
Chaperone Binding
Biological Process
NLS-bearing Protein Import Into Nucleus
Modulation By Virus Of Host Process
Viral Entry Into Host Cell
Protein-containing Complex Assembly
Viral Penetration Into Host Nucleus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Response To Hypoxia
Placenta Development
Potassium Ion Transport
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Regulation Of Exit From Mitosis
Notch Signaling Pathway
Heart Development
Sensory Perception Of Sound
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Glucose
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Positive Regulation Of Microtubule Polymerization
Response To Estradiol
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Response To Drug
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Response To Peptide Hormone
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Response To Cadmium Ion
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Cellular Component Movement
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Response To Organic Cyclic Compound
Mitotic Cell Cycle Arrest
Regulation Of Lens Fiber Cell Differentiation
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Pathways
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
Prostate cancer
GWAS
Inflammatory skin disease (
25574825
)
Menopause (age at onset) (
22267201
)
Obesity-related traits (
23251661
)
Triiodothyronine/thyroxine ratio (
30824882
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Prostate cancer (
31562322
29892016
)
Systemic lupus erythematosus (
23273568
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
33 interacting genes:
APOL6
ARNT
CDKN1B
COIL
DDX21
EPAS1
EPHA2
ERCC3
FAM50B
FTL
GATA6
GTF2H1
GTF2IRD1
HIF1A
HNRNPC
HSPB1
KPNB1
MAT2B
MVP
MYOD1
NFE2L2
NFKB1
NUP50
RBBP4
RCC1
RPRD1A
SLC5A11
TEX37
TGM2
TSSC4
ZBTB24
ZCCHC10
ZNF131
70 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL1
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MYC
NUP50
PIN1
PSMB1
RBX1
RCHY1
RNF123
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2I
UBE2L3
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
3839
1027
HPRD ID
03536
02867
Ensembl ID
ENSG00000102753
ENSG00000111276
Uniprot IDs
A0A024RDV7
O00505
P46527
Q6I9V6
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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