TRIM23 and SPG21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM23	SPG21
Description		tripartite motif containing 23	SPG21 abhydrolase domain containing, maspardin
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Plasma Membrane	Golgi Apparatus Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleic Acid Binding GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding GDP Binding Identical Protein Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Intracellular Protein Transport Viral Process Vesicle-mediated Transport Protein Ubiquitination Positive Regulation Of Catalytic Activity Innate Immune Response	Antigen Receptor-mediated Signaling Pathway
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		151 interacting genes: - ACTN4 AKTIP ANKRD36BP1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 BAZ2B C19orf57 C8orf33 CARD9 CCDC146 CCDC25 CDC20B CDR2 CFAP53 COX5B CREB5 CXCL14 CYTH1 CYTH2 DCX DEPP1 DMC1 DMRT3 DNAAF4 DOCK2 EAF2 EXOC3-AS1 FAM110A FAM133A FAM193B FAM83A FAM90A1 FBF1 FHIT FLAD1 FXR2 GAD1 GATA2 GCC2-AS1 GEM GGA2 GLIDR GMCL2 GPANK1 GPKOW HAUS1 HNRNPLL HOXB5 HSPB7 IQCE IQUB JOSD1 KAT5 KIFC3 KLHL42 KRT6A LGALS3 LGALS8 LINC00526 LINC01018 LMO2 LNX1 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MTFR2 NEK6 NFU1 NXT2 PDE4D PHF1 PIAS2 PIK3R2 PITX1 PKP4 POLI POLL POM121 PPIL2 PPP1R18 PSMA1 RAD18 RAMAC RIBC2 RNF126 RNF213 RNF32 RNF34 RNF6 RSRC2 RTP5 SF1 SH2D4A SIAH1 SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SORBS3 SPG21 STK19 SUMO1P1 TASOR2 TBC1D22B TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TROAP TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U UBE2W UBOX5 USP2 USP20 USP21 UTP23 WDR25 ZC2HC1C ZNF250 ZNF564 ZNF581 ZNF688	37 interacting genes: AGTRAP AKIRIN2 ARL6IP1 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 LMNA MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		373	51324
HPRD ID		03449	10492
Ensembl ID		ENSG00000113595	ENSG00000090487
Uniprot IDs		P36406	A0A024R5Y1 Q9NZD8
PDB IDs		5VZV 5VZW
Enriched GO Terms of Interacting Partners?
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