SPG21 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPG21	CRYAA
Description		SPG21 abhydrolase domain containing, maspardin	crystallin alpha A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding CD4 Receptor Binding	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Antigen Receptor-mediated Signaling Pathway	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Protein Stabilization Response To Stimulus
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		37 interacting genes: AGTRAP AKIRIN2 ARL6IP1 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 LMNA MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263	17 interacting genes: ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP NTAQ1 SDCBP SPG21
Entrez ID		51324	1409
HPRD ID		10492	00427
Ensembl ID		ENSG00000090487	ENSG00000160202
Uniprot IDs		A0A024R5Y1 Q9NZD8	A0A140G945 P02489
PDB IDs
Enriched GO Terms of Interacting Partners?
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