TRIM23 and FHIT

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TRIM23	FHIT
Description		tripartite motif containing 23	fragile histidine triad diadenosine triphosphatase
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Plasma Membrane	Fibrillar Center Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Nucleic Acid Binding GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding GDP Binding Identical Protein Binding	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Intracellular Protein Transport Viral Process Vesicle-mediated Transport Protein Ubiquitination Positive Regulation Of Catalytic Activity Innate Immune Response	Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways
Drugs			Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases			Non-small cell lung cancer Small cell lung cancer
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Broad depression or schizophrenia ( 30626913) Bronchopulmonary dysplasia ( 23897914) Caudal anterior-cingulate cortex volume ( 31530798) Cognitive function ( 25644384) Conotruncal heart defects ( 24800985) Depressive symptom measurement or major depressive disorder ( 28049566) Differentiated thyroid cancer ( 28703219) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Intracranial aneurysm ( 29531279) Iris color (L* coordinate) ( 30895295) Irritable bowel syndrome ( 29673008) Lung function (maximal voluntary ventilation) ( 29095316) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643) Major depressive disorder ( 20125088) Methadone dose in opioid dependence ( 28115739) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Papillary thyroid cancer ( 28703219) Pars triangularis volume ( 31530798) Photic sneeze reflex ( 27182965) Postoperative myocardial infarction after cardiac surgery ( 30678657) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553) Schizophrenia ( 30285260) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		151 interacting genes: - ACTN4 AKTIP ANKRD36BP1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 BAZ2B C19orf57 C8orf33 CARD9 CCDC146 CCDC25 CDC20B CDR2 CFAP53 COX5B CREB5 CXCL14 CYTH1 CYTH2 DCX DEPP1 DMC1 DMRT3 DNAAF4 DOCK2 EAF2 EXOC3-AS1 FAM110A FAM133A FAM193B FAM83A FAM90A1 FBF1 FHIT FLAD1 FXR2 GAD1 GATA2 GCC2-AS1 GEM GGA2 GLIDR GMCL2 GPANK1 GPKOW HAUS1 HNRNPLL HOXB5 HSPB7 IQCE IQUB JOSD1 KAT5 KIFC3 KLHL42 KRT6A LGALS3 LGALS8 LINC00526 LINC01018 LMO2 LNX1 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MTFR2 NEK6 NFU1 NXT2 PDE4D PHF1 PIAS2 PIK3R2 PITX1 PKP4 POLI POLL POM121 PPIL2 PPP1R18 PSMA1 RAD18 RAMAC RIBC2 RNF126 RNF213 RNF32 RNF34 RNF6 RSRC2 RTP5 SF1 SH2D4A SIAH1 SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SORBS3 SPG21 STK19 SUMO1P1 TASOR2 TBC1D22B TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TROAP TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U UBE2W UBOX5 USP2 USP20 USP21 UTP23 WDR25 ZC2HC1C ZNF250 ZNF564 ZNF581 ZNF688	9 interacting genes: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I
Entrez ID		373	2272
HPRD ID		03449	03096
Ensembl ID		ENSG00000113595	ENSG00000189283
Uniprot IDs		P36406	A0A024R366 P49789
PDB IDs		5VZV 5VZW	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?
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