JAK1 and EIF2AK2

Number of citations of the paper that reports this interaction (PubMedID 17290288)
14

Data Source:
HPRD (in vivo)

		JAK1	EIF2AK2
Description		Janus kinase 1	eukaryotic translation initiation factor 2 alpha kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Focal Adhesion Membrane	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Positive Regulation Of Sprouting Angiogenesis	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Regulation of IFNA signaling	ISG15 antiviral mechanism Inhibition of PKR
Drugs		Myricetin 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Ruxolitinib Tofacitinib Baricitinib
Diseases
GWAS		Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Sum eosinophil basophil counts ( 27863252)	Glucose homeostasis traits ( 25524916)
Interacting Genes		71 interacting genes: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6	49 interacting genes: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 ZNF346
Entrez ID		3716	5610
HPRD ID		00992	01468
Ensembl ID		ENSG00000162434	ENSG00000055332
Uniprot IDs		P23458 Q6P669	P19525 Q8IW76
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D	1QU6 2A19 2A1A 3UIU 6D3K 6D3L
Enriched GO Terms of Interacting Partners?
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