EIF2AK2 and ZNF346

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EIF2AK2	ZNF346
Description		eukaryotic translation initiation factor 2 alpha kinase 2	zinc finger protein 346
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding	RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Enzyme Binding MiRNA Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Positive Regulation Of Apoptotic Process
Pathways		ISG15 antiviral mechanism Inhibition of PKR
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916)	Height ( 28552196 31562340) Type 2 diabetes ( 30718926) Uterine fibroids ( 30194396 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 ZNF346	5 interacting genes: ANKHD1 EIF2AK2 ILF3 TARBP2 XPO5
Entrez ID		5610	23567
HPRD ID		01468	05606
Ensembl ID		ENSG00000055332	ENSG00000113761
Uniprot IDs		P19525 Q8IW76	B7Z4J8 B7Z4N4 Q9UL40
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L	2MKD 2MKN
Enriched GO Terms of Interacting Partners?
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