EIF2AK2 and ILF3

Number of citations of the paper that reports this interaction (PubMedID 11438536)
51

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		EIF2AK2	ILF3
Description		eukaryotic translation initiation factor 2 alpha kinase 2	interleukin enhancer binding factor 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Protein Phosphorylation Negative Regulation Of Translation Negative Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Defense Response To Virus
Pathways		ISG15 antiviral mechanism Inhibition of PKR
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Height ( 25282103 25429064) Ischemic stroke ( 29531354) Obesity-related traits ( 23251661) Psoriasis ( 25903422 25574825 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 30423114) Stroke ( 29531354) Systemic lupus erythematosus ( 28714469)
Interacting Genes		49 interacting genes: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 ZNF346	30 interacting genes: DHX9 EIF2AK2 EP300 ERG ESR1 FUS GDF9 HNRNPH2 IL7R KRTAP4-12 LNX1 MAGEA11 MDFI NDRG1 PLSCR1 PRMT1 PRMT5 RBM5 RBPMS RNF113A SF1 SF3B4 SMN1 SNRPC TRIP6 UBC XAB2 XPO5 ZNF346 ZNF830
Entrez ID		5610	3609
HPRD ID		01468	04420
Ensembl ID		ENSG00000055332	ENSG00000129351
Uniprot IDs		P19525 Q8IW76	A0A024R7C7 Q12906
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L	2L33 3P1X
Enriched GO Terms of Interacting Partners?
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