EIF2AK2 and MOV10

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (pull down)

		EIF2AK2	MOV10
Description		eukaryotic translation initiation factor 2 alpha kinase 2	Mov10 RISC complex RNA helicase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	P-body Extracellular Space Nucleus Cytosol Cytoplasmic Stress Granule Viral Replication Complex Cytoplasmic Ribonucleoprotein Granule P Granule
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding	RNA Binding Protein Binding ATP Binding 5'-3' RNA Helicase Activity
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Transposition, RNA-mediated Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Posttranscriptional Gene Silencing By RNA Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Megakaryocyte Differentiation Defense Response To Virus Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Regulation Of Neuron Projection Arborization
Pathways		ISG15 antiviral mechanism Inhibition of PKR	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Glucose homeostasis traits ( 25524916)	Blood pressure ( 21909110) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 31562340) Hip circumference adjusted for BMI ( 25673412) Hypertension ( 21909115 25249183 30487518) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (diuretics) ( 31015401) Systolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		49 interacting genes: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 ZNF346	4 interacting genes: ADORA3 ATP5PB EIF2AK2 TSPAN2
Entrez ID		5610	4343
HPRD ID		01468	14732
Ensembl ID		ENSG00000055332	ENSG00000155363
Uniprot IDs		P19525 Q8IW76	Q5JR04 Q9HCE1
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L
Enriched GO Terms of Interacting Partners?
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