INSR and RACK1

Number of citations of the paper that reports this interaction (PubMedID 16382134)
45

Data Source:
HPRD (in vitro, in vivo)

		INSR	RACK1
Description		insulin receptor	receptor for activated C kinase 1
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GO Annotations	Cellular Component	Nuclear Envelope Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Receptor Complex Extracellular Exosome	Phagocytic Cup Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex
	Molecular Function	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Protein Domain Specific Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Homodimerization Activity Ribosome Binding Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Receptor-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Learning Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Male Gonad Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Male Sex Determination Adrenal Gland Development Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of Protein Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Anatomical Structure Development Positive Regulation Of Meiotic Cell Cycle Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Neuron Projection Maintenance Regulation Of Female Gonad Development	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production
Drugs		Insulin Human Insulin Lispro Insulin Glargine Insulin Pork Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin Degludec Brigatinib	Copper
Diseases		Rabson-Mendenhall syndrome Leprechaunism ; Donohue syndrome
GWAS		Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) Hip circumference adjusted for BMI ( 28552196 25673412) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Serum uric acid levels ( 30993211) Systolic blood pressure ( 28135244 27841878 28739976 27618448 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Triglyceride levels ( 28334899) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969) Urate levels ( 31578528 23263486)
Interacting Genes		86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB	99 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ATG14 ATG5 AURKB BCL2L11 BECN1 BRCA1 CCNA1 CDKN1A CHERP CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FBXW7 FYN GABRB3 GATA4 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 WDR83
Entrez ID		3643	10399
HPRD ID		00975	01503
Ensembl ID		ENSG00000171105	ENSG00000204628
Uniprot IDs		P06213	E9KL35 P63244
PDB IDs		1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF	4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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