RACK1 and BECN1

Number of citations of the paper that reports this interaction (PubMedID 24166503)
11

Data Source:
BioGRID (pull down)

		RACK1	BECN1
Description		receptor for activated C kinase 1	beclin 1
Image
GO Annotations	Cellular Component	Phagocytic Cup Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex	Phagophore Assembly Site Cell Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Extrinsic Component Of Membrane Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Homodimerization Activity Ribosome Binding Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol 3-kinase Binding GTPase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Mitotic Metaphase Plate Congression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Protein Localization By The Cvt Pathway Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Cell Division Defense Response To Virus Negative Regulation Of Cell Death Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production	Macroautophagy Ub-specific processing proteases
Drugs		Copper	Estradiol
Diseases
GWAS			Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		99 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ATG14 ATG5 AURKB BCL2L11 BECN1 BRCA1 CCNA1 CDKN1A CHERP CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FBXW7 FYN GABRB3 GATA4 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 WDR83	50 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 ITCH KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 NF2 PDGFRA PGK1 RACK1 RAF1 SHD SMAD2 STK11 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1
Entrez ID		10399	8678
HPRD ID		01503	05087
Ensembl ID		ENSG00000204628	ENSG00000126581
Uniprot IDs		E9KL35 P63244	A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4
PDB IDs		4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP	2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK
Enriched GO Terms of Interacting Partners?
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