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RACK1 and FYN
Number of citations of the paper that reports this interaction (PubMedID
11943848
)
77
Data Source:
HPRD
(in vivo, in vitro)
RACK1
FYN
Description
receptor for activated C kinase 1
FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Phagocytic Cup
Cell
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Small Ribosomal Subunit
Cytosolic Small Ribosomal Subunit
Dendrite
Midbody
Neuronal Cell Body
Perikaryon
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
IRE1-RACK1-PP2A Complex
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
RNA Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Ion Channel Inhibitor Activity
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Enzyme Binding
Protein Phosphatase Binding
Protein Tyrosine Kinase Inhibitor Activity
Cyclin Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Homodimerization Activity
Ribosome Binding
Cadherin Binding
BH3 Domain Binding
Molecular Adaptor Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Disordered Domain Specific Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Cycle
Gastrulation
Negative Regulation Of Gene Expression
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Protein Ubiquitination
Negative Regulation Of Translation
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Complex Assembly
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Golgi To Plasma Membrane Protein Transport
Positive Regulation Of Apoptotic Process
Pigmentation
Positive Regulation Of GTPase Activity
Rhythmic Process
Negative Regulation Of Phagocytosis
Regulation Of Cell Division
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Mitochondrial Depolarization
Negative Regulation Of Protein Tyrosine Kinase Activity
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Rescue Of Stalled Ribosome
Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Regulation Of Establishment Of Cell Polarity
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Gastrulation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
MAPK Cascade
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Blood Coagulation
Learning
Feeding Behavior
Regulation Of Cell Shape
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Proliferation
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Defense Response To Virus By Virus
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FLT3 Signaling
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Copper
Dasatinib
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Bipolar disorder (
31043756
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Interacting Genes
99 interacting genes:
ACTN2
ADH1B
ADRB2
AGTRAP
AR
ATG14
ATG5
AURKB
BCL2L11
BECN1
BRCA1
CCNA1
CDKN1A
CHERP
CSF2RB
DDX19B
DNM1
DYNLL1
EED
EIF6
ELOB
EP300
EPOR
ESR1
ESS2
FBXW7
FYN
GABRB3
GATA4
GNB1
GOLM1
GRAP2
GRIN2B
HABP4
HIF1A
HNRNPH2
IFNAR1
IFNAR2
IGF1R
IK
IL2RB
IL4R
IL7R
INSR
ITGB1
ITGB2
ITGB5
ITGB7
JAK1
LARP4B
LRP12
MAPK6
MCPH1
MKRN2
MTNR1A
NFATC1
NR3C1
NSMAF
OLA1
PABPC1
PDE4D
PIK3R4
PLCG1
PLEC
PRKAA1
PRKAB2
PRKCA
PRKCB
PRKCD
PRKCE
PRKD1
PRPF31
PTN
PTOV1
PTPRM
RASA1
RASA3
RB1
RHOA
SAT1
SLC27A6
SLC6A3
SRC
SREK1
ST7
STAT1
STAT3
SUMO4
SYT1
TARDBP
TBXA2R
TNFRSF1A
TP63
TP73
TSC22D4
TUBB
TUBG1
TYK2
WDR83
190 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DOK1
DOK3
DOK4
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
EVL
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HDAC2
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
Entrez ID
10399
2534
HPRD ID
01503
00655
Ensembl ID
ENSG00000204628
ENSG00000010810
Uniprot IDs
E9KL35
P63244
P06241
PDB IDs
4AOW
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6FEC
6G18
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
Enriched GO Terms of Interacting Partners
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