RACK1 and PTPRM

Number of citations of the paper that reports this interaction (PubMedID 11278757)
34

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RACK1	PTPRM
Description		receptor for activated C kinase 1	protein tyrosine phosphatase receptor type M
Image
GO Annotations	Cellular Component	Phagocytic Cup Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Homodimerization Activity Ribosome Binding Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug Positive Regulation Of Blood Vessel Diameter
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production
Drugs		Copper
Diseases
GWAS			Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)
Interacting Genes		99 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ATG14 ATG5 AURKB BCL2L11 BECN1 BRCA1 CCNA1 CDKN1A CHERP CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FBXW7 FYN GABRB3 GATA4 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 WDR83	11 interacting genes: BCCIP CDH1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1
Entrez ID		10399	5797
HPRD ID		01503	01479
Ensembl ID		ENSG00000204628	ENSG00000173482
Uniprot IDs		E9KL35 P63244	P28827
PDB IDs		4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP	1RPM 2C9A 2V5Y
Enriched GO Terms of Interacting Partners?
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