FOXA3 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		FOXA3	TLE2
Description		forkhead box A3	TLE family member 2, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Actin Cytoskeleton	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Cellular Glucose Homeostasis Chromatin Organization Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Cellular Response To Starvation Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Regulation of gene expression in beta cells	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		5 interacting genes: ALX4 HMGB1 PPARA TLE1 TLE2	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		3171	7089
HPRD ID		03802	03025
Ensembl ID		ENSG00000170608	ENSG00000065717
Uniprot IDs		A0A024R0R3 P55318	K7EMK7 Q04725
PDB IDs		1VTN
Enriched GO Terms of Interacting Partners?
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