HTT and SETD2

Number of citations of the paper that reports this interaction (PubMedID 9700202)
116

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		HTT	SETD2
Description		huntingtin	SET domain containing 2, histone lysine methyltransferase
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleoplasm Chromosome
	Molecular Function	P53 Binding Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To ER Apoptotic Process Golgi Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Microtubule-based Transport Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Viral Process Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin
Pathways		Regulation of MECP2 expression and activity	PKMTs methylate histone lysines
Drugs		Copper
Diseases		Huntington's disease (HD)
GWAS		Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monobrow ( 27182965) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		109 interacting genes: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655	8 interacting genes: ATXN1 CIC H3-4 H3C1 HTT SIAH2 SMAD3 SPOP
Entrez ID		3064	29072
HPRD ID		00883	11043
Ensembl ID		ENSG00000197386	ENSG00000181555
Uniprot IDs		P42858	Q9BYW2
PDB IDs		2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C	2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22
Enriched GO Terms of Interacting Partners?
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