GTF2H1 and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		GTF2H1	POU2AF1
Description		general transcription factor IIH subunit 1	POU class 2 homeobox associating factor 1
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex	RNA Polymerase II Transcription Factor Complex
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Nucleotide-excision Repair, DNA Incision Positive Regulation Of Transcription By RNA Polymerase II Phosphorylation Of RNA Polymerase II C-terminal Domain Global Genome Nucleotide-excision Repair	Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 28240269) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944) Survival in pancreatic cancer ( 28470677)	Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		44 interacting genes: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 PIK3R1 PLCG1 POLR2A POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	19 interacting genes: GATA2 GCC2 GTF2H1 GTF2I MSX2 NAB1 NOTCH1 PAX8 POU2F1 POU2F2 PTPN11 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		2965	5450
HPRD ID		01807	03126
Ensembl ID		ENSG00000110768	ENSG00000110777
Uniprot IDs		A0A384MTQ8 P32780	Q16633
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M	1CQT
Enriched GO Terms of Interacting Partners?
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