GTF2H1 and BRPF1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		GTF2H1	BRPF1
Description		general transcription factor IIH subunit 1	bromodomain and PHD finger containing 1
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	DNA Binding Protein Binding Histone Acetyltransferase Activity (H3-K23 Specific) Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Nucleotide-excision Repair, DNA Incision Positive Regulation Of Transcription By RNA Polymerase II Phosphorylation Of RNA Polymerase II C-terminal Domain Global Genome Nucleotide-excision Repair	Histone H3 Acetylation Histone H3-K23 Acetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 28240269) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944) Survival in pancreatic cancer ( 28470677)
Interacting Genes		44 interacting genes: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 PIK3R1 PLCG1 POLR2A POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	3 interacting genes: GTF2H1 H3C14 PBXIP1
Entrez ID		2965	7862
HPRD ID		01807	03875
Ensembl ID		ENSG00000110768	ENSG00000156983
Uniprot IDs		A0A384MTQ8 P32780	P55201
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M	2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8 4LC2 4QYD 4QYL 4UYE 5C6S 5C7N 5C85 5C87 5C89 5D7X 5DY7 5DYA 5DYC 5E3D 5E3G 5EM3 5EPR 5EPS 5EQ1 5ERC 5ETB 5ETD 5EV9 5EVA 5EWC 5EWD 5EWH 5EWV 5EWW 5FFV 5FFW 5FFY 5FG4 5FG5 5G4R 5G4S 5MWG 5MWH 5MWZ 5MYG 5O4S 5O4T 5O55 5O5A 5O5F 5O5H 5OV8 5OWA 5OWB 5OWE 5T4U 5T4V 6EKQ 6U04
Enriched GO Terms of Interacting Partners?
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