GSPT1 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 27338790)
48

Data Source:
BioGRID (enzymatic study, pull down)

		GSPT1	CRBN
Description		G1 to S phase transition 1	cereblon
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GO Annotations	Cellular Component	Cytosol Translation Release Factor Complex	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Regulation Of Translational Termination Protein Methylation	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Guanosine-5'-Diphosphate	Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Height ( 28552196) Menopause (age at onset) ( 26414677) Testicular germ cell tumor ( 26503584)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		12 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CRBN DDB1 ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP	33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		2935	51185
HPRD ID		00753	16750
Ensembl ID		ENSG00000103342	ENSG00000113851
Uniprot IDs		B2RCT6 P15170 Q7KZX8	Q96SW2
PDB IDs		3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
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