GRIN2D and CIT

Number of citations of the paper that reports this interaction (PubMedID 10862698)
341

Data Source:
HPRD (in vivo)

		GRIN2D	CIT
Description		glutamate ionotropic receptor NMDA type subunit 2D	citron rho-interacting serine/threonine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Postsynaptic Membrane Postsynaptic Density Membrane	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Cleavage Furrow
	Molecular Function	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Scaffold Protein Binding
	Biological Process	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	RHO GTPases activate CIT RHO GTPases activate CIT
Drugs		Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Orphenadrine Phenobarbital Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS			Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		2906	11113
HPRD ID		04095	09289
Ensembl ID		ENSG00000105464	ENSG00000122966
Uniprot IDs		O15399 Q59G17	O14578
PDB IDs
Enriched GO Terms of Interacting Partners?
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