CIT and RHOC

Number of citations of the paper that reports this interaction (PubMedID 8543060)
56

Data Source:
HPRD (two hybrid, in vitro)

		CIT	RHOC
Description		citron rho-interacting serine/threonine kinase	ras homolog family member C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Cleavage Furrow	Cytoplasm Cytosol Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Division Site Cleavage Furrow Stereocilium Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Scaffold Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process	Mitotic Cytokinesis Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT	Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372)
Interacting Genes		16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG	7 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 ROCK1 RTKN
Entrez ID		11113	389
HPRD ID		09289	01322
Ensembl ID		ENSG00000122966	ENSG00000155366
Uniprot IDs		O14578	A0A024R0C8 P08134
PDB IDs			1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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