GRIN2D and FUS

Number of citations of the paper that reports this interaction (PubMedID 10862698)
341

Data Source:
HPRD (in vivo)

		GRIN2D	FUS
Description		glutamate ionotropic receptor NMDA type subunit 2D	FUS RNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Postsynaptic Membrane Postsynaptic Density Membrane	Nucleus Nucleoplasm Polysome Perikaryon Dendritic Spine Head Perinuclear Region Of Cytoplasm
	Molecular Function	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Estrogen Receptor Binding Myosin V Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of RNA Splicing MRNA Stabilization Protein Homooligomerization Cellular Response To Calcium Ion Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	mRNA Splicing - Major Pathway
Drugs		Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Orphenadrine Phenobarbital Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	45 interacting genes: AKT1 ARID1A ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TARDBP TDRD3 THRA TNIP1 UBQLN2 WBP4 YBX1 ZMYM2
Entrez ID		2906	2521
HPRD ID		04095	00660
Ensembl ID		ENSG00000105464	ENSG00000089280
Uniprot IDs		O15399 Q59G17	P35637 Q13344 Q6IBQ5
PDB IDs			2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?