CIT and RHOB

Number of citations of the paper that reports this interaction (PubMedID 8543060)
56

Data Source:
BioGRID (far western blotting, two hybrid)

		CIT	RHOB
Description		citron rho-interacting serine/threonine kinase	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Cleavage Furrow	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cell Division Site Cleavage Furrow Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Scaffold Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process	Mitotic Cytokinesis Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT	GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs			Botulinum Toxin Type A
Diseases
GWAS		Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG	12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1
Entrez ID		11113	388
HPRD ID		09289	01321
Ensembl ID		ENSG00000122966	ENSG00000143878
Uniprot IDs		O14578	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?