CEP57L1 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CEP57L1	ALOX5
Description		centrosomal protein 57 like 1	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Centrosome Microtubule	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Plasma Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Molecular_function Protein Binding Microtubule Binding Identical Protein Binding Gamma-tubulin Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
	Biological Process	Biological_process	Leukocyte Chemotaxis Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Lipid Oxidation Interleukin-18-mediated Signaling Pathway Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Hepoxilin Biosynthetic Process Oxidation-reduction Process Lipoxin Biosynthetic Process
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Diacerein Rhein
Diseases
GWAS		Midgestational circulating levels of PCBs ( 28235828) Prostate cancer ( 23535732)	Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		74 interacting genes: AKT1 ALOX5 AP1M1 ARNT2 BRCA1 BYSL CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CDR2 CEP44 CEP55 CEP63 CEP70 CFAP206 DISC1 DYDC1 ELOA EXOC8 FAM161A FAM9B GADD45G GOLGA1 GOLGA2 HAUS1 HDDC3 HGS IKZF1 KATNAL1 KIFC3 KLC3 KLC4 KRT13 KRT19 KRT31 KRT38 KRT40 LENG1 LMO3 LZTS2 MAGEA1 MAGEA2B MDFI MEOX2 MFAP1 MID2 MORF4L1 MTUS2 MYO15B NEFL NOTCH1 NUP62 PKN1 PNMA5 PPL RAD51D RINT1 ROPN1 SNAP47 SNAPC3 TAB3 TFIP11 TRAF2 TRAPPC2L TRIM54 TRIP6 TSGA10 TXLNA TXLNB VPS28 ZGPAT	19 interacting genes: ACTB ALOX5AP ALPL APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 MTDH NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		285753	240
HPRD ID		10792	01065
Ensembl ID		ENSG00000183137	ENSG00000012779
Uniprot IDs		E5RFY4 G3V140 Q8IYX8	P09917
PDB IDs			2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?
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