ALOX5 and NUTM1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ALOX5	NUTM1
Description		arachidonate 5-lipoxygenase	NUT midline carcinoma family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Plasma Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm
	Molecular Function	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen	Protein Binding
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Lipid Oxidation Interleukin-18-mediated Signaling Pathway Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Hepoxilin Biosynthetic Process Oxidation-reduction Process Lipoxin Biosynthetic Process
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs		Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Diacerein Rhein
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		19 interacting genes: ACTB ALOX5AP ALPL APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 MTDH NUTM1 REL SYCE1 TGFBRAP1	23 interacting genes: ALOX5 AXIN1 CCHCR1 FAM161A HSPBAP1 IFIT2 KANSL1 KPNA2 LHX8 LMO1 LMO2 LMO3 MORN4 NEBL P4HA3 PRKAA2 PSME4 RIC8A SAMD4A SH2D4A TP53BP2 ZMYND10 ZNF277
Entrez ID		240	256646
HPRD ID		01065	10606
Ensembl ID		ENSG00000012779	ENSG00000184507
Uniprot IDs		P09917	Q86Y26
PDB IDs		2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?
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