CEP57L1 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CEP57L1	PKN1
Description		centrosomal protein 57 like 1	protein kinase N1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Centrosome Microtubule	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex
	Molecular Function	Molecular_function Protein Binding Microtubule Binding Identical Protein Binding Gamma-tubulin Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Biological_process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Midgestational circulating levels of PCBs ( 28235828) Prostate cancer ( 23535732)	Urolithiasis ( 30975718)
Interacting Genes		74 interacting genes: AKT1 ALOX5 AP1M1 ARNT2 BRCA1 BYSL CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CDR2 CEP44 CEP55 CEP63 CEP70 CFAP206 DISC1 DYDC1 ELOA EXOC8 FAM161A FAM9B GADD45G GOLGA1 GOLGA2 HAUS1 HDDC3 HGS IKZF1 KATNAL1 KIFC3 KLC3 KLC4 KRT13 KRT19 KRT31 KRT38 KRT40 LENG1 LMO3 LZTS2 MAGEA1 MAGEA2B MDFI MEOX2 MFAP1 MID2 MORF4L1 MTUS2 MYO15B NEFL NOTCH1 NUP62 PKN1 PNMA5 PPL RAD51D RINT1 ROPN1 SNAP47 SNAPC3 TAB3 TFIP11 TRAF2 TRAPPC2L TRIM54 TRIP6 TSGA10 TXLNA TXLNB VPS28 ZGPAT	39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282
Entrez ID		285753	5585
HPRD ID		10792	03019
Ensembl ID		ENSG00000183137	ENSG00000123143
Uniprot IDs		E5RFY4 G3V140 Q8IYX8	Q16512
PDB IDs			1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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