DOK7 and APPL1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		DOK7	APPL1
Description		docking protein 7	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Plasma Membrane Cell Junction Synapse	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	Lipid Binding Protein Kinase Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Positive Regulation Of Protein Tyrosine Kinase Activity	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases		Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Calcium levels ( 29403010) Fibrinogen levels ( 28107422) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		7 interacting genes: APPL1 BCAR1 CRK EFHC1 MPZL1 MUSK YPEL3	45 interacting genes: ADIPOR1 ADIPOR2 AKT1 AKT2 APPL2 BATF3 BRWD1 CBL CBLB CMTM4 DCC DOK2 DOK3 DOK7 DPYSL5 EGFR FARS2 FSHR HDAC2 ID1 IMPDH2 INO80E KLF15 KXD1 MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 PIK3CA PIK3R1 PIK3R2 PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 TP53 TRAF2 UBE2O ZNF829
Entrez ID		285489	26060
HPRD ID		08744	05053
Ensembl ID		ENSG00000175920	ENSG00000157500
Uniprot IDs		A0A1W2PRA3 Q18PE1 Q8N1M3	Q9UKG1
PDB IDs			2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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