APPL1 and DOK2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		APPL1	DOK2
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	docking protein 2
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Cytosol
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Viral Process Leukocyte Migration
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Tie2 Signaling RET signaling
Drugs
Diseases
GWAS			Entorhinal cortical thickness ( 21116278) Mean corpuscular volume ( 20139978) Metabolite levels ( 23823483) Neuropathic pain in type 2 diabetes ( 24974787) Verbal declarative memory ( 25648963)
Interacting Genes		45 interacting genes: ADIPOR1 ADIPOR2 AKT1 AKT2 APPL2 BATF3 BRWD1 CBL CBLB CMTM4 DCC DOK2 DOK3 DOK7 DPYSL5 EGFR FARS2 FSHR HDAC2 ID1 IMPDH2 INO80E KLF15 KXD1 MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 PIK3CA PIK3R1 PIK3R2 PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 TP53 TRAF2 UBE2O ZNF829	20 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK
Entrez ID		26060	9046
HPRD ID		05053	05411
Ensembl ID		ENSG00000157500	ENSG00000147443
Uniprot IDs		Q9UKG1	B4DKQ6 O60496
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	2D9W 2DLW
Enriched GO Terms of Interacting Partners?
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