APPL1 and ADIPOR1

Number of citations of the paper that reports this interaction (PubMedID 16622416)
199

Data Source:
BioGRID (two hybrid, protein complementation assay)
HPRD (in vivo, two hybrid, in vitro)

		APPL1	ADIPOR1
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	adiponectin receptor 1
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Hormone-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Negative Regulation Of Cell Growth Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Negative Regulation Of JAK-STAT Cascade Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS			Mean platelet volume ( 27863252)
Interacting Genes		45 interacting genes: ADIPOR1 ADIPOR2 AKT1 AKT2 APPL2 BATF3 BRWD1 CBL CBLB CMTM4 DCC DOK2 DOK3 DOK7 DPYSL5 EGFR FARS2 FSHR HDAC2 ID1 IMPDH2 INO80E KLF15 KXD1 MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 PIK3CA PIK3R1 PIK3R2 PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 TP53 TRAF2 UBE2O ZNF829	6 interacting genes: APPL1 CEP350 DPH3 NAA20 NFKBIL1 STK11
Entrez ID		26060	51094
HPRD ID		05053	06402
Ensembl ID		ENSG00000157500	ENSG00000159346
Uniprot IDs		Q9UKG1	Q96A54
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	3WXV 5LXG
Enriched GO Terms of Interacting Partners?
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