APPL1 and DOK7

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		APPL1	DOK7
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	docking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Nucleoplasm Mitochondrion Plasma Membrane Cell Junction Synapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Lipid Binding Protein Kinase Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases			Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS			Calcium levels ( 29403010) Fibrinogen levels ( 28107422) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		45 interacting genes: ADIPOR1 ADIPOR2 AKT1 AKT2 APPL2 BATF3 BRWD1 CBL CBLB CMTM4 DCC DOK2 DOK3 DOK7 DPYSL5 EGFR FARS2 FSHR HDAC2 ID1 IMPDH2 INO80E KLF15 KXD1 MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 PIK3CA PIK3R1 PIK3R2 PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 TP53 TRAF2 UBE2O ZNF829	7 interacting genes: APPL1 BCAR1 CRK EFHC1 MPZL1 MUSK YPEL3
Entrez ID		26060	285489
HPRD ID		05053	08744
Ensembl ID		ENSG00000157500	ENSG00000175920
Uniprot IDs		Q9UKG1	A0A1W2PRA3 Q18PE1 Q8N1M3
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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