RNF115 and CST3

Number of citations of the paper that reports this interaction (PubMedID 22315970)
11

Data Source:
BioGRID (two hybrid)

		RNF115	CST3
Description		ring finger protein 115	cystatin C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Basement Membrane Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Axon Nuclear Membrane Neuronal Cell Body Contractile Fiber Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Eye Development Response To Hypoxia Apoptotic Process Defense Response Brain Development Salivary Gland Development Embryo Implantation Positive Regulation Of Cell Proliferation Response To Carbohydrate Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Response To Nutrient Levels Response To Estradiol Regulation Of Tissue Remodeling Circadian Sleep/wake Cycle, REM Sleep Regulation Of Programmed Cell Death Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Proteolysis Response To Axon Injury Sertoli Cell Development Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Supramolecular Fiber Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Breast cancer ( 25751625 29059683)	Blood protein levels ( 30072576 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		31 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
Entrez ID		27246	1471
HPRD ID		18328	05056
Ensembl ID		ENSG00000265491	ENSG00000101439
Uniprot IDs		Q9Y4L5	A0A0K0K1J1 P01034
PDB IDs			1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
Enriched GO Terms of Interacting Partners?
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