CST3 and CTSL

Number of citations of the paper that reports this interaction (PubMedID 10428479)
2

Data Source:
HPRD (in vitro)

		CST3	CTSL
Description		cystatin C	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Axon Nuclear Membrane Neuronal Cell Body Contractile Fiber Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Plasma Membrane Endolysosome Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Eye Development Response To Hypoxia Apoptotic Process Defense Response Brain Development Salivary Gland Development Embryo Implantation Positive Regulation Of Cell Proliferation Response To Carbohydrate Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Response To Nutrient Levels Response To Estradiol Regulation Of Tissue Remodeling Circadian Sleep/wake Cycle, REM Sleep Regulation Of Programmed Cell Death Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Proteolysis Response To Axon Injury Sertoli Cell Development Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Supramolecular Fiber Organization	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Collagen Catabolic Process Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs			Cysteinesulfonic Acid Felbinac
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blood protein levels ( 30072576 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	28 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		1471	1514
HPRD ID		05056	00293
Ensembl ID		ENSG00000101439	ENSG00000135047
Uniprot IDs		A0A0K0K1J1 P01034	A0A024R276 P07711 Q9HBQ7
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06
Enriched GO Terms of Interacting Partners?
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