CST3 and CSTB

Number of citations of the paper that reports this interaction (PubMedID 1996959)
26

Data Source:
BioGRID (enzymatic study)

		CST3	CSTB
Description		cystatin C	cystatin B
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Axon Nuclear Membrane Neuronal Cell Body Contractile Fiber Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Eye Development Response To Hypoxia Apoptotic Process Defense Response Brain Development Salivary Gland Development Embryo Implantation Positive Regulation Of Cell Proliferation Response To Carbohydrate Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Response To Nutrient Levels Response To Estradiol Regulation Of Tissue Remodeling Circadian Sleep/wake Cycle, REM Sleep Regulation Of Programmed Cell Death Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Proteolysis Response To Axon Injury Sertoli Cell Development Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Supramolecular Fiber Organization	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Negative Regulation Of Proteolysis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Neutrophil degranulation
Drugs			Cupric Chloride
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	9 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1471	1476
HPRD ID		05056	03091
Ensembl ID		ENSG00000101439	ENSG00000160213
Uniprot IDs		A0A0K0K1J1 P01034	P04080 Q76LA1
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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