CST3 and CTSD

Number of citations of the paper that reports this interaction (PubMedID 2013314)
15

Data Source:
HPRD (in vitro)

		CST3	CTSD
Description		cystatin C	cathepsin D
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Axon Nuclear Membrane Neuronal Cell Body Contractile Fiber Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity
	Biological Process	Eye Development Response To Hypoxia Apoptotic Process Defense Response Brain Development Salivary Gland Development Embryo Implantation Positive Regulation Of Cell Proliferation Response To Carbohydrate Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Response To Nutrient Levels Response To Estradiol Regulation Of Tissue Remodeling Circadian Sleep/wake Cycle, REM Sleep Regulation Of Programmed Cell Death Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Proteolysis Response To Axon Injury Sertoli Cell Development Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Supramolecular Fiber Organization	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Catabolic Process Collagen Catabolic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Regulation Of Establishment Of Protein Localization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression
Drugs			Insulin Human Insulin Pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
Interacting Genes		9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	23 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NLGN3 PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG
Entrez ID		1471	1509
HPRD ID		05056	00291
Ensembl ID		ENSG00000101439	ENSG00000117984
Uniprot IDs		A0A0K0K1J1 P01034	P07339 V9HWI3
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
Enriched GO Terms of Interacting Partners?
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