AMFR and DERL1

Number of citations of the paper that reports this interaction (PubMedID 16186510)
141

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		AMFR	DERL1
Description		autocrine motility factor receptor	derlin 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Signal Recognition Particle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Binding, Bridging Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Protease Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Polyubiquitination Protein Folding Ubiquitin-dependent Protein Catabolic Process Signal Transduction Aging Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: BAG6 CRMP1 CSNK2A2 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 SOD1 TOM1L1 TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	11 interacting genes: AMFR APP CFTR HLA-A LMNA MELTF RHO SELENOS TCF25 UBXN6 VCP
Entrez ID		267	79139
HPRD ID		09130	12302
Ensembl ID		ENSG00000159461	ENSG00000136986
Uniprot IDs		A0A024R6R5 Q9UKV5	A0A024R9G3 E5RGY0 Q9BUN8
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD	5GLF
Enriched GO Terms of Interacting Partners?
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