AMFR and HERPUD1

Number of citations of the paper that reports this interaction (PubMedID 17310145)
110

Data Source:
BioGRID (enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology)

		AMFR	HERPUD1
Description		autocrine motility factor receptor	homocysteine inducible ER protein with ubiquitin like domain 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Lewy Body Core
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Binding, Bridging Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Molecular_function Protein Binding Ion Channel Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination
	Biological Process	Protein Polyubiquitination Protein Folding Ubiquitin-dependent Protein Catabolic Process Signal Transduction Aging Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Total cholesterol levels ( 29403010) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		28 interacting genes: BAG6 CRMP1 CSNK2A2 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 SOD1 TOM1L1 TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP	16 interacting genes: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6
Entrez ID		267	9709
HPRD ID		09130	07456
Ensembl ID		ENSG00000159461	ENSG00000051108
Uniprot IDs		A0A024R6R5 Q9UKV5	A4UAE9 Q15011 Q53FP9
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD	1WGD
Enriched GO Terms of Interacting Partners?
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