GDNF and AGTRAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		GDNF	AGTRAP
Description		glial cell derived neurotrophic factor	angiotensin II receptor associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Cortex Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance	Angiotensin Type II Receptor Activity Protein Binding
	Biological Process	MAPK Cascade Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	Signaling by BRAF and RAF fusions
Drugs		Chondroitin sulfate
Diseases		Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS)
GWAS		Asthma ( 29273806) Major depressive disorder ( 20125088)	Systolic blood pressure ( 19430483)
Interacting Genes		5 interacting genes: AGTRAP GFRA1 GFRA2 NCAM1 RET	79 interacting genes: ACSF2 AGTR1 AGTR2 ALDH18A1 AP3M1 ARAF ARFIP2 ARHGAP1 BPIFA2 CAPNS1 CD160 CIAO2A COQ8A CPLX1 CRCT1 DDA1 DDX55 DGCR6 DIABLO ECPAS FAM114A1 FAM160A2 FARS2 FASTKD3 FATE1 FGA GABARAPL2 GAD1 GAD2 GDNF GTF3C1 H4C7 HARS2 HMGB1 HSCB HSPA4 ISCU LMNA LMO2 LNX1 MCEE MIEF1 MIEF2 MRM1 MTERF3 MUTYH MYG1 NDRG4 NFU1 NFYB NKG7 PBX3 PCTP PDHX PIMREG PITPNC1 PNPO PTPN9 RACK1 RMDN2 S100B SENP2 SNX1 SPG21 SSX3 SSX5 STAG3L1 SUCLA2 SYT16 TBRG4 TCEANC2 TFAM TMEM14B TPD52L3 TUBA1B TXN2 UBE2I ZFYVE21 ZNF391
Entrez ID		2668	57085
HPRD ID		02906	16379
Ensembl ID		ENSG00000168621	ENSG00000177674
Uniprot IDs		A0A0S2Z3T2 A0A0S2Z3V2 P39905	Q6RW13
PDB IDs		2V5E 3FUB 4UX8 6Q2N
Enriched GO Terms of Interacting Partners?
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