GDNF and NCAM1

Number of citations of the paper that reports this interaction (PubMedID 12837245)
144

Data Source:
HPRD (in vivo)

		GDNF	NCAM1
Description		glial cell derived neurotrophic factor	neural cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Golgi Membrane Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance	Virus Receptor Activity
	Biological Process	MAPK Cascade Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway	MAPK Cascade Cell Adhesion Axon Guidance Viral Entry Into Host Cell Interferon-gamma-mediated Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling
Drugs		Chondroitin sulfate
Diseases		Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS)
GWAS		Asthma ( 29273806) Major depressive disorder ( 20125088)	Age at first sexual intercourse ( 27089180) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878)
Interacting Genes		5 interacting genes: AGTRAP GFRA1 GFRA2 NCAM1 RET	19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		2668	4684
HPRD ID		02906	00301
Ensembl ID		ENSG00000168621	ENSG00000149294
Uniprot IDs		A0A0S2Z3T2 A0A0S2Z3V2 P39905	A0A087WWD4 P13591
PDB IDs		2V5E 3FUB 4UX8 6Q2N	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
Enriched GO Terms of Interacting Partners?
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